Checkerboard testing method indicates synergic effect of pelgipeptins against multidrug resistant Klebsiella pneumoniae
نویسندگان
چکیده
منابع مشابه
In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae.
BACKGROUND Resistance to colistin is emerging in multidrug-resistant Gram-negative bacteria and no solid pharmacodynamic data are available for colistin against Klebsiella pneumoniae. METHODS Twenty-one multidrug-resistant clinical K. pneumoniae isolates from 16 different clinical sites worldwide were employed. The genetic relatedness of these isolates was examined with PFGE. In vitro pharmac...
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Objective(s): To evaluate the in vitro interaction between different extracts of Thymbra spicata L. and certain antimicrobial drugs of different mechanisms, including ampicillin, cefotaxime, amikacin and ciprofloxacin. This study was performed against multidrug-resistant strains of Staphylococcus aureus and Klebsiella pneumoniae. Materials and Methods: Evaluation of antibacterial activity and ...
متن کاملThree Dimensional Checkerboard Synergy Analysis of Colistin, Meropenem, Tigecycline against Multidrug-Resistant Clinical Klebsiella pneumonia Isolates
The spread of carbapenem-non-susceptible Klebsiella pneumoniae strains bearing different resistance determinants is a rising problem worldwide. Especially infections with KPC (Klebsiella pneumoniae carbapenemase) - producers are associated with high mortality rates due to limited treatment options. Recent clinical studies of KPC-blood stream infections revealed that colistin-based combination t...
متن کاملIn Vitro Synergism Testing of Three Antimicrobial Agents against Multidrug - Resistant and Extensively Drug - Resistant Mycobacterium tuberculosis by Checkerboard Method
Objective: In view of the national key project for infectious diseases “ the retreatment research of tuberculosis”, we determined the in vitro anti-mycobacterial activity of four drugs in the treatment, pasiniazid (Pa), moxifloxacin (Mfx), Rifabutin (Rfb) and rifapentini (Rft) in combination to multidrug-resistant and extensively drug-resistant mycobacterium tuberculosis. Method: Three-dimensio...
متن کاملMolecular characterization of multidrug-resistant Klebsiella pneumoniae isolates
Klebsiella pneumoniae is an important cause of healthcare-associated infections worldwide. Selective pressure, the extensive use of antibiotics, and the conjugational transmission of antibiotic resistance genes across bacterial species and genera facilitate the emergence of multidrug-resistant (MDR) K. pneumoniae. Here, we examined the occurrence, phenotypes and genetic features of MDR K. pneum...
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ژورنال
عنوان ژورنال: Biotechnology Research and Innovation
سال: 2019
ISSN: 2452-0721
DOI: 10.1016/j.biori.2018.12.001